The active site in the alphabeta barrel structures is usually located Gate Biotechnology 2014 question paper

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The active site in the alpha/beta barrel structures is usually located (-Gate Biotechnology 2014 question paper

(A) inside the barrel 
(B) at the amino side of the strands 
(C) at the carboxy side of the strands 
(D) at any arbitrary site


By:Aparna-Dasgupta

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At the carboxy side of the strands 

Alpha-Beta domains are the most commonly observed domain structure. In general, they consist of parallel or mixed beta sheets connected and surrounded by alpha helices. Alphabeta barrels ---Alpha-beta barrels must have at least 8 parallel beta strands (can be more) that form a closed circle and enclose a hydrophobic core. Cross connections between the parallel beta strands are alpha helices as in the beta-alpha-beta motif. All alpha helices are on one side of the beta sheet. The active site of all alpha-beta barrels is found in a pocket formed when carboxy ends of parallel strands loop to connect to amino ends of adjacent alpha helices. 

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