The 4 amino or 4 keto group of pyrimidine bases is located in the Gate Biotechnology 2014 question paper
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The 4-amino or 4-keto group of pyrimidine bases is located in the: (-Gate Biotechnology 2014 question paper)

(A) major groove of the double stranded DNA 
(B) minor groove of the double stranded DNA 
(C) minor groove of the B form DNA but not the A form DNA 
(D) major groove of the B form DNA but not the A form DNA


By:Aparna-Dasgupta

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Major groove of the double stranded DNA 

In B-DNA, guanine will hydrogen bond to a water molecule from both the minor groove 2- amino- and major groove 6-keto-groups with further single hydration on the free ring nitrogen atoms (minor groove N3 and major groove N7). Cytosine will hydrogen bond to a water molecule from both the major groove 4-amino- and minor groove 2-keto-groups. Adenine will hydrogen bond to a water molecule from the major groove 6-amino-group with further single hydration on the free ring nitrogen atoms (minor groove N3 and major groove N7). Thymine (and uracil, if base-paired in RNA) will hydrogen bond to a water molecule from both the minor groove 2-keto- and major groove 4-keto-groups. Phosphate hydration in the major groove is thermodynamically stronger but exchanges faster. 

tarun101

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